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Vitamin B12 is an important component of a healthy diet, contributing to the functioning of the brain, nerves and blood cells
Prior to the synthesis and isolation of these peptides, research into accelerated tissue healing and recovery relied largely on broad growth factors and nonspecific interventions

Trial registration The study protocol was approved by the ethics committee of Guilan University of Medical Sciences (IR.GUMS.REC.1400.197) in accordance with the World Medical Associations code of ethics (Declaration of Helsinki, revised in Brazil 2013), and registered at an ICMJE and WHO recognized registry of clinical trials ( www.irct.ir ) on 28/08/2021 (registration number: IRCT20200920048782N1).

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