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In a HF model with coarctation of the aorta, mice fed a high-cholesterol diet had higher TMAO levels and accelerated adverse ventricular remodeling (105)

At 6 wk of age, mice underwent a battery of behavioural tests (described in detail below) while treatment continued

If these degraded purine metabolites are not quickly rescued, they leak out of the cell membrane and are washed away into the bloodstream, permanently depleting the cell's total energy pool

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