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3a), with two uncharacterised metabolites as the strongest predictors (Supplementary Data 3), whilst meat intake was well predicted with just 2 metabolites (behenoylcarnitine (C22)* and arachidoylcarnitine (C20)*) (AUC = [Original TwinsUK: 0.83, Subset TwinsUK = 0.79], Supplementary Fig

Several clinical trials have found that treatment with propionyl-L-carnitine improves exercise tolerance in some patients with intermittent claudication

In addition, when the circulating L-carnitine concentration increases, as in the case of oral supplementation, the renal reabsorption of L-carnitine may become saturated, resulting in the increased urinary excretion of L-carnitine

It also contains somewhat underwhelming doses of shilajit and tongkat ali, at 250mg and 100mg, respectively

doi: 10.1093/toxsci/kfu105