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In diet-induced obesity (DIO) models, NNMT loss-of-function and selective small-molecule inhibitors reduce white adipose mass and improve metabolic parameters without overt toxicity, positioning NNMT as a tractable target for metabolic-disease research [24]

PMID 3927946

ATTAIN-2 (NCT05872620) This trial evaluated orforglipron in adults with obesity or overweight who also had type 2 diabetes, a critically important subpopulation given the high co-prevalence of these conditions

For phentermine, long-term outcome data is sparse precisely because the drug was never intended for long-term use

In the complex therapy of liver diseases (hepatitis, cirrhosis, liver steatosis)