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Oxidative stress may cause damages to lipids, proteins, and DNAs in cells, with subsequent disease development in humans 13

N., Troev D

Furthermore, TSN disrupts Wnt/-catenin signaling by inhibiting upstream molecules like DVL2 and activating the -catenin degradation complex (APC, AXIN1, CK1, GSK3)

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We previously also established a valid HUA animal model to explore urate-lowering therapy and organ protection (Li et al., 2021
