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The peptide exists as a copper chelate with high affinity for Cu(II) ions

Quantified fractions of target RNA bound across AGOmiRNA dilutions were fit to a quadratic equation by nonlinear least-squares regression in R using the LevenbergMarquardt algorithm (nlsLM from the R package minpack.lm): where F bound represents fraction of target bound, [target T ] represents the concentration of total target oligonucleotide, [stock] represents stock concentration of RISC, DF represents the dilution factor, K D represents the dissociation constant for the affinity between RISC and the target and F max represents the maximal fraction of target bound at the plateau

On the one hand, copper can directly bind to growth factors related to angiogenesis, enhancing their affinity to endothelial cells (94)

O.GiebultowiczJ

ROSE was used to define enhancers and superenhancers (67)