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While there is little research, anecdotal reports have found that taking vitamin B12 supplements before and after drinking alcohol can help replenish lost nutrients to recover more quickly from hangover symptoms

The animal data suggest lean mass is preserved, but human body composition data is lacking

SAM is a methyl group donor for numerous methylation reactions in the brain, including those involved in the metabolism of neurotransmitters whose deficiency has been related to depression (102)

As progress is made, the frequency might be adjusted to bi-weekly or monthly to maintain consistent energy levels and support ongoing metabolic function