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glutcose 6 phosphate dehydrogenase glutathione reductase Glucose-6-phosphate (G6PD) pathway. G6PD, Pentose Phosphate Pathway - The
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We hope to provide inspiration and ideas for future studies in the mechanism and targets of HO-1 through this review.
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Collectively, our study identifies the L2HGDH-L2HG axis as a previously unrecognized metabolic checkpoint controlling ferroptosis sensitivity in liver cancer and uncovers glutathione degradation as a therapeutically exploitable vulnerability for ferroptosis-based treatment strategies in HCC.
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