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The synthesis of the different thyroid hormones occurs in 5 steps as in Fig
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A sample size of 24 participants was chosen to provide 80% power to detect a treatment effect of a 0.5 standard deviation difference in mean IGF-1 area under the curve (AUC) response, assuming a within participant correlation of 0.7 and an alpha of 0.05
PMID: 31445908
