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Variants in SLC52A2/A3 , FLAD1, and folate-cycle genes alter riboflavin transport or FAD turnover, modulating clinical response

Petersen EA, Stauss TG, Scowcroft JA, Brooks ES, White JL, Sills SM, et al

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Specifically, melatonin suppresses proinflammatory cytokines (e.g., IL-1, IL-6, tumor necrosis factor- (TNF-), and interferon- (IFN-)) and enhances anti-inflammatory cytokines (e.g., IL-4 and IL-10) by inhibiting the NF-B pathway, although its low-dose transient proinflammatory effects highlight dose- and pathology-dependent dynamics