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Hypersensitivity to NSAIDs or history of bleeding disorders, such as GI bleeding or hemophilia Not recommended during pregnancy, but may be valuable in treating preeclampsia-eclampsia

Uric acid is the byproduct of purine nucleotide catabolism

Annu Rev Nutr (2005) 25:21535

When early aphthous ulcers are biopsied, the histologic appearance shows a dense inflammatory infiltrate, 80% of which is made up of T cells