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[DOI] [PMC free article] [PubMed] [Google Scholar] Hess R, Menzel D
368,369,370 HSF2 and DLG2 can block the oligomerization of ASC by interfering with the interaction between ASC and NLRP3, thereby inhibiting the activation of the NLRP3 inflammasome and the upregulation of IL-1 expression and alleviating the inflammatory response
& Martins, J
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To explore the PK and effect of multiple doses on safety-related endpoints and plasma lipids and biomarkers, another 50 healthy individuals were randomized into a multiple-ascending dose (MAD) trial (Fig
Table 4 Relevant indicators of the study sample
