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Additionally, targeted phosphorylation of cytoplasmic FOXO factors by JNK promotes nuclear import and increases cellular protection against OS via the transcriptional activation of MnSOD and CAT [118]
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Compared with the more generalized phenomenological metabolism models, our model features 183 processes: 95 enzymatic reactions
doi: 10.12688/f1000research.20906.1 139
Additionally, benfotiamine mitigated oxidative stress and mitochondrial dysfunction and activated Nrf2/ARE pathway in this model, showing its potential to be used in treatment for diseases with tau pathology [21]
