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Horikawa K, Martin SW, Pogue SL, Silver K, Peng K, Takatsu K, et al

It plays a fundamental role in counterattacking the overproduction of reactive oxygen species (ROS) [1] that often occurs under cell injury conditions and that may lead, when uncontrolled, to the development of several types of diseases, including cancer [2]

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Becher J, et al

HFCD-fed rats displayed hyperlipidemia and increased oxidative stress, as indicated by a significant rise in blood and liver lipid profiles, an increase in plasma conjugated diene concentration, an increase in liver thiobarbituric acid reactive substances (TBARS) level, and a significant decrease in manganese superoxide dismutase (Mn-SOD) activity compared with rats fed normal diet