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We further explore the crosstalk among different RCD pathways and their integrated effects on disease progression

ROS and necroptosis can form a necroptotic loop: ROS stabilizes receptor interacting protein kinase 3 (RIP3) to promote the necrosome formation, while RIP3 enhances ROS generation through metabolic signaling [152]

The Study: What Did They Do

Informed consent was obtained from a parent of each child (who also assented to study participation)
