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Biotin deficiency has been directly associated with hair loss and brittle hair, therefore, is a common ingredient in many supplements for healthy hair

[DOI] [PubMed] [Google Scholar] Verhulst I, MacLennan K, Haffey A, et al

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Xu C, Sun L, Ren F, et al

Future research should aim to assess the clinical efficacy of B 12 replacement therapy in treating CU symptoms, possibly by comparing symptom relief in groups of patients receiving standard CU treatment alone versus those receiving B 12 supplementation