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(PubMed) Franke B, Vermeulen SH, Steegers-Theunissen RP, et al

In addition, antagonists of corticotropin-releasing factor 1 (CRF 1) have some antidepressant and anti-anxiety effects [69, 70], via mechanisms possibly related to the involvement of CRF 1 in the hypothalamic-pituitary-adrenal (HPA) axis [58]
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