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Women who are pregnant or breastfeeding should not use MOTs-C

[DOI] [PMC free article] [PubMed] [Google Scholar] Manish P., Antonio J., Ding W., Salomon S., Todd B., Randy S., Ravit G., Shivaani K., Patrick R., Ruth P., Patricia L., Shilpa G., Sima Z., Andressa L., Oleg M., Josh F., Sheryl C., Stephanie P., William R., Praveen A., Lisa J., Khanh D., Robert M., Ryan S

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For instance, in skin cancer cells, EGCG significantly decreased the proteins levels of DNMT1, DNMT3a, and DNMT3b and modulated the HDAC activities allowing the transcriptional activation of tumor suppressor genes such as p16 INK4a and Cip1/p21

The exhaustive efforts to overcome the hurdles in the transepithelial delivery of peptides and proteins can fuel the application of CPP-aided nasal drug delivery in the clinical settings