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Because plasma concentrations fall below therapeutic threshold within six to eight hours, single daily dosing is standard

Pyridoxines use in pregnancy, often in combination with doxylamine, has not been associated with teratogenic effects in either the first trimester or later trimesters

For patients who have not previously been diagnosed with vitamin B12 deficiency or prescribed a vitamin B12 injection, the medicine can be offered if vitamin B12 deficiency is suspected based on signs, symptoms and/or risk factors, though confirmation of vitamin B12 deficiency by a reliable test kit should also be considered

Patients often describe their skin as feeling "bouncier" or more firm

Proc Natl Acad Sci USA 102, 1554515550 (2005)