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Description
After PLC- is activated by Gq, phosphatidylinositol 4,5- bisphosphate (PIP2) is hydrolyzed into diacylglycerol (DAG) and inositol 1,4,5-triphosphate (IP3) (54)
et al., 1999
Pilomatricomas are mostly circumscribed, cystic lesions that are present in the dermis and subcutis
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The conformational flexibility of TM11 appears to be linked with substrate recognition, with R471 (responsible for carnitine coordination) located near the midpoint of this helix, between the two segments that bend during the transition between inward-facing and occluded conformations
