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Some studies have found a higher rate of vitamin B12 deficiency in people with MS than in people without MS

Supplementary Material Acknowledgments: The authors are grateful to the study participants enrolled in protocols for making this study possible

It would be interesting to investigate whether other protein-secreting cells, like pancreatic cells producing insulin 31 or hepatocytes secreting albumin 32 , depend on PPP-generated NADPH for protein folding as well and are also susceptible to proteotoxicity in hypoxia

This is the direct-repair option, and the one researchers reach for when they want to skip the pituitary step