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however, it also reduces metal ions that generate free radicals through the Fenton reaction [25]
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Additionally, the increase in local interstitial tissue temperature enhances lymphatic and blood flow, aiding the migration of T cells and APCs
In addition, carrier-free nanoparticles GEM-CXB NPs formed by the nano self-assembly of the dual drugs gemcitabine and celecoxib, exhibit dual clearance of MDSCs and tumor cells thereby significantly enhancing antitumor effects by inducing ICD and alleviating MDSC-induced immunosuppression through MDSCs clearance (134)
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