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Description
Semaglutide activates GLP-1 receptors in the pancreas, gut, and hypothalamus to reduce appetite, slow gastric emptying, and improve glycemic control
Accessed 8 Oct

Yes, but classical swallowed peptides are largely destroyed by gastric acid and digestive enzymes
There is also an indication of some neuronal synthesis, yet the majority of insulin in the brain is of peripheral origin
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