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Its key feature lies in the competitive utilization of the same substrate by iNOS (also known as Nos2) and Arg1: the former generates NO and is closely associated with pro-inflammatory effects, whereas the latter produces ornithine and polyamines and participates in tissue repair and immune regulation ( Under classical pro-inflammatory stimulation (such as LPS/IFN-), iNOS expression is upregulated and catalyzes the conversion of Arg into NO and citrulline

doi: 10.1042/BJ20051578

GD1a-IgG (2 mg total per mouse) was delivered via intraperitoneal injection on postoperative days 3, 5, 7, 9, 11, and 13

Diabetes mellitus: the linkage between oxidative stress, inflammation, hypercoagulability and vascular complications

Am J Clin Nutr 2003;77:1241-7