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As has been noted, individuals are only as old as their arteries*5, maintaining vascular function is linked not only to cardiovascular health but also to the maintenance of overall health, including cognitive function, kidney function, motor function, and even mood

The sophisticated process of mitochondrial biogenesis requires coordination between mtDNA and nDNA, including mtDNA transcription and translation, translation of nDNA-encoded transcripts, membrane recruitment, protein import, and assembly of the OXPHOS complexes (Wu et al., 1999), and PPARG coactivator 1 beta (PGC1) along with PPARG related-coactivator 1 (PRC) were discovered subsequently (Lin et al., 2002)

The least squares geometric means in Table 2 are derived from the mixed model

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PNI can result in permanent functional deficits with severe impacts on the quality of life and productivity of those affected 4,5,6,7