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The study missed its primary endpoint because this was based on a log-transformed mean of the 24-h data which obscured the beneficial morning suppression of 17OHP

SOD converts O 2 (a highly reactive free radical) to H 2 O 2 (a less reactive free radical), which can then be further broken down by catalase to yield water (H 2 O) and oxygen (O 2 )

doi: 10.1002/alz.054142 48 CevikSESkaarDAJimaDDLiuAJstbyeTWhitsonHEet al

HbA1c reference ranges (IFCC, UK standard): Below 42 mmol/mol : Normal no evidence of diabetes or prediabetes 4247 mmol/mol : Non-diabetic hyperglycaemia (prediabetes) increased risk of developing type 2 diabetes 48 mmol/mol or above : Diagnostic of type 2 diabetes (when confirmed on a second venous laboratory sample, or on a single sample in the presence of symptoms) HbA1c results can be affected by a number of conditions