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Autophagy deficiency in neurons results in buildup of ubiquitinated proteins, dystrophy of neural terminals, impairments in synaptic transmission, and eventually, neurodegeneration observed in both neurodegenerative and neurodevelopmental disorders [245, 249, 250]

This allows for faster regeneration of ATP during high-intensity training, helping athletes: Lift heavier weights Perform more reps Recover faster between sets Experience enhanced gains in strength and lean muscle mass Clinical studies confirm that creatine supplementation is associated with improved training performance , increased muscular hypertrophy , and greater improvements in strength and speed over time (Kreider et al., Journal of Strength and Conditioning Research )

ICS should therefore be used with caution in patients with COPD, especially among those with a previous history of pneumonia, and if indicated, should be used in the lowest possible dose