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JAMA Neurol 2020;77(8):10001007

But in fact, the term pernicious anemia means a specific vitamin B12 deficiency caused by the loss of the bodys ability to make intrinsic factor. Intrinsic factor is in the lining of the stomach, so a weakened stomach lining (which is called atrophic gastritis can cause pernicious anemia

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Administered directly into the muscle, they bypass the digestive system to ensure maximum absorption