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Gating mechanism of the extracellular entry to the lipid pathway in a TMEM16 scramblase

The study adhered to the principles of the Declaration of Helsinki and was approved by the Institutional Ethics Committee of the Eye and Ears, Nose, and Throat Hospital, Fudan University (No.2024215)

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These observations recommend caution regarding the therapeutic potential of 25HC ( In vitro , 27OH inhibits infection of SARS-CoV-2 and HCoV-OC43 (175), an aspect of the regulation of the inflammatory response not investigated so far in coronavirus infection