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These features make it highly susceptible to oxidative damage due to a high concentration of easily oxidizable polyunsaturated fatty acids, iron and metals, as well as the neuronal metabolic rate which mediates the continuous production of ROS [31]
Macfarlan, T
Chronic administration of BMS309403 improves endothelial function in apolipoprotein E-deficient mice and in cultured human endothelial cells
In pathological conditions astroglial cells undergo multiple progressive and/or regressive changes, which can to a significant extent determine the progression and outcome of neurological diseases as discussed below
