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1 , e1400223 (2015)

Amended safety assessment of amorphous silica and synthetically-manufactured amorphous silicates as used in cosmetics
Monitor oxidative stress to determine the extent of cell damage using a colorimetric gluthathione assay

No tolerance development to the lipolytic effects was noted in these studies, suggesting that unlike beta-2 agonists (which rapidly desensitize their receptors), beta-3 receptor activation may not produce the same downregulation pattern
