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Vitamin K was the only vitamin not included in the supplement, and the level did not significantly change (+15%, n.s.) during the study

However, at pH 5.0, the protein exists in dimer-tetramer equilibrium (30% dimer and 70% tetramer) beyond which it purely exists in its tetrameric state till pH 3.0
doi: 10.1016/j.bbagen.2012.09.008 34 GingrasACRaughtBSonenbergN

These conventional DMARDs do not provide immediate symptom relief it can take weeks to months before you can tell whether the drug is working for you
Biomolecules 10 (1), 59