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In ergothioneine biosynthesis, the combination of a mononuclear non-heme iron enzyme catalyzed oxidative C-S bond formation reaction and a PLP-mediated C-S lyase (EgtE) reaction results in a net sulfur transfer from cysteine to histidine side-chain

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In the HT+C21+EMPA group, histopathological damage score in hematoxylineosin (HE) stained heart sections compared to the HT group showed a decrease in tissue damage but cell infiltration was still observed