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In fact, dysregulation of autophagy is a common feature in neurodegenerative diseases, where impaired autophagic flux contributes to the accumulation of damaged proteins and organelles, exacerbating neuronal stress and degeneration [85,86]

These hepatic pathological changes in OXA-induced ALI were different from the pathology of chronic liver injuries induced by multi-cycle OXA-based chemotherapy reported in clinical observation and animal studies, in which the primary characteristics of liver injury are liver sinusoidal injury and SOS (2,3)

New generation biomarkers and multi-omic approaches MASLD has a globally increasing prevalence and has the potential to progress to its more severe form, MASH

However, in lung diseases cellular damage and injury is mediated by an increased oxidant burden and/or decreased antioxidant defenses