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The most well characterized and clinically significant CTRH subtype is that induced by vascular endothelial growth factor (VEGF) pathway inhibitors

Growth hormone peptides: Can cause water retention, joint pain, carpal tunnel symptoms, insulin resistance (with long-term high-dose use), increased hunger (especially GHRP-6, GHRP-2)

Experiments are designed to quantify its effects on collagen I and III synthesis (via qPCR or Western blot), myofibroblast differentiation (by measuring -smooth muscle actin expression), and the critical MMP/TIMP balance

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and muscular disorders (eg, muscle weakness, myalgia)