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Our findings support the rationale of using blood DNA as a surrogate of brain tissue to analyze changes in CpG methylation level in patients with neurodegenerative diseases, opening the possibility for characterizing new biomarkers

10 shows the percentage of conjugates remaining intact as a function of time (i.e., relative deconjugation), after initial conjugation (100%), for Q-tag sequence WPAQGPT (SEQ ID NO: 8) conjugated to benzylamine linker L38 and L-amino acid-benzylamine linkers (L41, L42, and L44)

13 , 2026

doi: 10.1007/s00296-017-3702-9

Intralesional steroid administration will not prevent the development of alopecia areata at other sites and is not suitable for patients with rapidly progressive patchy alopecia areata, alopecia totalis or alopecia universalis