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Therapeutic potential of mesenchymal stem cells in a pre-clinical model of diabetic kidney disease and obesity

3-Hydroxy-3-methylglutaryl-CoA synthase 2 (HMGCS2), the rate-limiting enzyme of ketogenesis, is hypersuccinylated in the absence of SIRT5, but this modification of HMGCS2 inhibits its activity and reduces ketone body production (Rardin et al., 2013)

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We are also grateful to Andrea Grostl Dietz, Stephanie von Holstein-Rathlou, Kristian Nygaard Mortensen, Andrew James Samson, Simon Sanggaard, Mauro DiNuzzo, Camilla Dall, Celia Johanne Kjrby Palner, Benjamin Travis Kress, Harlan Albert Mullins, and Pia Crine Christensen for critically reading the manuscript