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As depression has been previously shown to be associated with changes in neurometabolites, mood and anxiety ratings were performed: the Beck Depression Inventory II (BDI-II) [30] for mood, the Spielberger State Anxiety Inventory (STAI) for anxiety [31]

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As of 2025, at least 22 industry-sponsored Phase 2 and 3 trials (with NCT registration) are underway, targeting conditions across gastroenterology, oncology, neonatology, dermatology, and neurology (Figure 2)

Increased plasma saturated fatty acids (SFAs), induced by a high fat diet, are mainly responsible for these pathologic progresses [3,4,5]