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Reduced concentrations of N-acetyl aspartate and total creatine in the basal ganglia are markers of neuronal loss and impaired energy metabolism, which correlate with cognitive dysfunction and motor deficits (Nordahl et al., 2005)
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Lancet 2 , 241246 (1974)

Still, to date evidence in this direction remains inconclusive, with no biomarker exhibiting sufficient accuracy to distinguish specific patient categories with target organ damage, despite its high prevalence among those with LC [67]
