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Furthermore, the adequate activation of alternative pathways should occur along with the additional (direct) beneficial effects on affected targets
Also, cancers that are capable of synthesizing asparagine de novo via asparagine synthetase are less responsive to asparaginase therapy
BMJ (2006) 333:575
Quintar A, McArdle S, Wolf D, Marki A, Ehinger E, Vassallo M, et al
Hepatitis B virus X protein induces TNF- expression via down-regulation of selenoprotein P in human hepatoma cell line, HepG2
