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149 Under specific conditions, ROS can bypass these pathways to induce pyroptosis, driven by inflammasome activation (e.g., NLRP3) in response to PAMPs/DAMPs, the predominance of inflammatory caspases (caspase-1/4/5/11) over caspase-8 or RIPK3, and cell-specific mechanisms prioritizing cytokine release (IL-1/IL-18) in immune cells like macrophages

It remains unknown why this aggregation occurs

[DOI] [PubMed] [Google Scholar] 164.Hung C.C., Lin C.H., Lane H.Y

That accident if you want to call it that launched fifty years of research across wound healing, collagen biology, gene expression, and a half-dozen other fields that werent even on anyones radar at the time

Pisano, C
