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The importance of the NRF2 system in Alzheimers disease has been documented by the fact that impairment of NRF2 in mouse models resulted in deteriorated cognitive abilities (Perluigi et al

chronic liver disease and hepatitis may present with elevated levels Renal impairment : Reduced clearance can contribute to accumulation, though this is rarely clinically significant Solid tumours : Certain malignancies, particularly hepatocellular carcinoma and metastatic disease, may elevate B12 levels [3] Evidence suggests that unexplained markedly elevated B12 levels without supplementation may sometimes be associated with underlying disease

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Hum Genomics