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Theres no question that the use of many of these has surged, in part because of their putative anti-aging effects or other unsubstantiated health claims, along with endorsements by celebrities, longevity, and wellness influencers

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A researcher reading the AOD-9604 literature should weight the single rigorous negative trial far more heavily than the cluster of smaller positive reports, because that is how evidence hierarchy works

It is just radically incomplete, and the gap between the mechanism story and the clinical reality is where most people using this compound get misled

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