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10.1016/j.yexcr.2012.01.020

A daily intake of approximately 6 microg vitamin B-12 appears to saturate all the vitamin B-12-related variables in Danish postmenopausal women

At this stage, the hematological defects are indistinguishable from those of folate deficiency and include megaloblastic anemia, characterized by macro-ovalocytic erythrocytes, abnormal red cell indices, and a low hemoglobin concentration (see Chapter 17, Sections 17.2.7 and 17.4)

Hemin and ferric ammonium citrate, but not biliverdin and bilirubin, promote erastin or FINO 2 -induced ferroptotic cell death

Notably, the ROS generated during ferroptosis further exacerbate mitochondrial damage (Jiang et al., 2021), forming a positive feedback loop of mitochondrial dysfunction-ferroptosis-excessive ROS-mitochondrial damage