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[DOI] [PubMed] [Google Scholar] Cooper A.J.L., Pinto J.T., Krasnikov B.F., Niatsetskaya Z.V., Han Q., Li J., Vauzour D., Spencer J.P.E

This regulation was shown to occur under the direct transcriptional control of GA-binding protein alpha (GABPA)a critical Ets-family transcription factor that acts as a master regulator of mitochondrial biogenesis by controlling the expression of nuclear-encoded mitochondrial proteins, and whose direct binding to the PHB2 promoter makes it a key upstream determinant of the cells capacity for mitophagy (60)

Anti-Aging Effects: The infusion of collagen, stem cells, and growth factors helps improve skin elasticity, reduce wrinkles, and rejuvenate the skin, resulting in a more youthful appearance

Conversely, inhibiting miR-134-5p reversed these effects and significantly improved BPD (Lan et al., 2023)

Proc Natl Acad Sci USA 105(7):22632265 Melnyk CW, Molnar A, Baulcombe DC (2011) Intercellular and systemic movement of RNA silencing