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10.3109/09637486.2012.713915 16 BabashpourS.PiriK.Saify-NabiabadH.SabouniF

314 , H1049H1052 (2018)

In diseases such as IPF, ferroptosis has been increasingly recognized as an important pathological mechanism involved in disease progression

Moreover, in Mycobacterium tuberculosis (Mtb) infection, Let-7f miRNAs can inhibit NF-B inhibitor A20 by targeting NF-B, promoting the polarization of M1 macrophages and NF-B activity (141)

In our study 92 , bradykinin, ATP, substance P and CGRP levels in BALF were increased in OVA mice, and these increases were augmented in OVA plus UFP-exposed mice and in NHBE cells with increasing UFP doses, suggesting that UFPs activate TRPVs and P2X7 and secrete neuromediators that lead to airway inflammation, exacerbating asthma