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& Ruas, J

KU-57788 induces excessive mitochondrial fission and fragmentation by directly binding to and activating DRP1, independent of its primary target DNA-PKcs

This is non-negotiable based on the clinical trial data

This aligns with the biology: repeated stimulation of the wound healing cascade and growth factor release compounds over time

MTT assay showed more than 70% cell viability on human bronchial epithelial cell line (16HBE14o-) and BCECs, indicating biosafety