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Although traditional clinical trials, such as the Saxagliptin Assessment of Vascular Outcomes Recorded in Patients with Diabetes Mellitus-Thrombolysis in Myocardial Infarction (SAVOR-TIMI) 53 study, demonstrated neutral effects on the progression of DKD in non-selective cohorts, certain subgroup analyses indicated a potential reduction in albuminuria among early-stage DKD patients (110)

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Studies using polysomnography have documented increased slow-wave sleep duration and improved sleep efficiency in subjects administered DSIP, with some research showing up to 30% increases in delta wave activity during the first sleep cycles