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DUBs remove ubiquitin from precursor proteins by either interacting with a large area surrounding the hydrophobic region of ubiquitin or by selectively identifying and hydrolyzing ester, peptide, or isopeptide linkages at the carboxy-terminal end of ubiquitin

doi: 10.1016/j.addr.2022.114635 [DOI] [PMC free article] [PubMed] [Google Scholar] 143.Stockwell BR, Jiang XJ

miR-128, targets B-lymphoma Mo-MLV insertion region 1 (BMI1) which promotes cell proliferation and tumor growth and binds to the promoter region of PTEN thereby suppressing its expression (57)

21 United States Environmental Protection Agency