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doi: 10.1097/MIB.0000000000000010, PMID: [DOI] [PubMed] [Google Scholar] 95

Recent studies suggest that mitochondrial dysfunction, secondary to a disruption of carnitine homeostasis, may also play a role in the loss of nitric oxide (NO) signaling and the development of endothelial dysfunction associated with a variety of cardiovascular diseases [2]

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Nat Rev Dis Primers 3: 17088, 2017

However, some animal and clinical studies have been conducted to assess the adverse impact of potential toxicity and to estimate safe levels of lysine supplements
